Search on: INSULIN RECEPTOR SUBSTRATE PROTEINS 
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Descriptor English:   Insulin Receptor Substrate Proteins 
Descriptor Spanish:   Proteínas Sustrato del Receptor de Insulina 
Descriptor Portuguese:   Proteínas Substratos do Receptor de Insulina 
Tree Number:   D12.644.360.024.301
D12.776.157.057.039
D12.776.476.024.382
Definition English:   A structurally-related group of signaling proteins that are phosphorylated by the INSULIN RECEPTOR PROTEIN-TYROSINE KINASE. The proteins share in common an N-terminal PHOSPHOLIPID-binding domain, a phosphotyrosine-binding domain that interacts with the phosphorylated INSULIN RECEPTOR, and a C-terminal TYROSINE-rich domain. Upon tyrosine phosphorylation insulin receptor substrate proteins interact with specific SH2 DOMAIN-containing proteins that are involved in insulin receptor signaling. 
History Note English:   2009(1992) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification CT contraindications
DF deficiency DU diagnostic use
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   53148 
Unique Identifier:   D055504 

Occurrence in VHL:
 

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